SPLUNC1 Loses Its Antimicrobial Activity in Acidic Cystic Fibrosis Airway Secretions
نویسندگان
چکیده
منابع مشابه
Acidic pH increases airway surface liquid viscosity in cystic fibrosis.
Cystic fibrosis (CF) disrupts respiratory host defenses, allowing bacterial infection, inflammation, and mucus accumulation to progressively destroy the lungs. Our previous studies revealed that mucus with abnormal behavior impaired mucociliary transport in newborn CF piglets prior to the onset of secondary manifestations. To further investigate mucus abnormalities, here we studied airway surfa...
متن کاملAirway clearance in cystic fibrosis.
Airway clearance is considered an integral component of standard therapy for cystic fibrosis (CF) patients. Although the pathophysiology of CF has not been conclusively delineated, most of the theories revolve around the development of viscous airway secretions.1–4 These secretions are thought to be poorly cleared from the lung, leading to airway obstruction and infection with Staphylococcus au...
متن کاملAirway remodelling and its relationship to inflammation in cystic fibrosis.
Pulmonary disease is the most important cause of morbidity and mortality in cystic fibrosis (CF). Most patients with CF die from respiratory failure with extensive airway destruction. Airway remodelling, defined as structural airway wall changes, begins early in life in CF but the sequence of remodelling events in the disease process is poorly understood. Airway remodelling in CF has traditiona...
متن کاملCYSTIC FIBROSIS Airway remodelling in children with cystic fibrosis
Background: The relationship between airway structural changes and inflammation is unclear in early cystic fibrosis (CF) lung disease. A study was undertaken to determine changes in airway remodelling in children with CF compared with appropriate disease and healthy controls. Methods: Bronchoalveolar lavage and endobronchial biopsy were performed in a cross-sectional study of 43 children with C...
متن کاملMUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.
Cystic fibrosis (CF) is characterized by progressive airway obstruction. Although it has been postulated that this is due in part to mucus hypersecretion, there are no published data showing an increase in the gel-forming mucins MUC5AC or MUC5B in CF secretions. We used confocal microscopy to assess the amount of mucin-like glycoprotein and DNA in CF sputum and found more mucin in bronchitis sp...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2019
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.201812-2303le